Looking to teach kids a little bit more about their nation's history, Canadian company Bitcasters has produced a mod for Civilization III. They are distributing the mod, along with 100,000 copies of the game, to schools around Canada.
I haven't had a whole lot of luck reading up on the details of the project, or how the whole thing came together. But, I have read the plan is to have a total of three mods that will give students an interactive history lesson, complete with related articles and evaluations. The first mod, called 'The New World', can be downloaded for free. A copy of Civilization II is required to play (which I do not have).
I'd be interested in seeing this thing in action, or at least hearing from someone who has. The game's message boards aren't really hopping, but there is a handful of positive feedback.
The idea of using the customizable nature of modern computer games to craft an e-learning experience isn't ground-breaking. But, this is the most promising example I've heard about. The advantages of using a stable, established engine (Civ III), can help a company avoid some of the problems associated with tech development, and focus more on the quality of the content.